The real detriment to your control scheme is that potion bar. If you got rid of it, you could put almost your entire panoply on 1-6, sh1-sh6, ctrl1-ctrl6, shctrl1-shctrl6, with a little bit of right hand buttoning on 0-=
Example:
If you play with mouse in hand, you could also set the 0-= bar slots to MiddleClick, Back, Forward; this could make mouseover targetting on Provoke or Salted Earth feel more natural.



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