In HW's you will need to do MSQ to open some zones to gather and craft. But clearing every quest in each zone will get you to 60 just before the last zone. As some of them have dungeon XP. I would just do MSQ and then use PoTD to fill the gaps in 2.0msq. As people are right a few times you get a spot where you can't activate next MSQ with out grinding some xp.