Quote Originally Posted by VKhaun View Post
Once I've got everything on cooldown there's not enough there to constantly be slowing me down.
When using macros, the game doesn't actually start even registering your button presses until the previous skill's GCD is finished, so in all situations you're losing a split second per skill simply because the next skill isn't being "pre-loaded" in the skill queue. That's just how it is, and like Rongway says, that split second per skill builds up very fast over time to become quite significant.

Even if you put every skill of a completely perfect DRG rotation in entirely separate macro buttons (just one skill per macro), the very fact that they'd be macros instead of regular weaponskills would mean that maintaining that rotation would quickly become impossible because you're constantly falling behind on every single button press. That alone should be reason enough not to do this at all - the fact that macros with multiple skills in them are unreliable and unpredictable only compounds the issue further.