This is happening to me, as well. However, I use a Mac, so cleaning registry isn't an option. It's not constant; it doesn't happen all the time. But when I choose to teleport OR I'm moving from one zone to another (such as moving into Waking Sands from Vesper Bay), the game crashes & has to be restarted. I don't get any error messages; the game just quits.

iMac 27", late 2013 (3.4 GHz Intel Core i5)
32 GB RAM
NVIDIA GeForce GTX with 2GB VRAM
Running OS 10.2.4

I did have an issue earlier with the game causing my entire Mac to reboot, but I found that my bluetooth speakers were interfering with the game; as long as I don't connect to the bluetooth speakers, there's no reboot. The issue with the game crashing on a teleport or zone move just started in the last two days.