I'm playing with all effects on, but I also only play ranged classes, so not actually seeing the boss because 5000 explosions are hitting him at once is not a problem.
Well, although, tbh, the main reason I don't play melee IS because of blinding effects
I just hate it even more to not see all effects in the overworld and the like, and having to constantly turn them on and off between instance and overworld would be even more annoying .-.