I use them to replace skills because ALL hotbars are full, there is no way for a simple hotbar switch. (My UI design is complex)
It doesnt matter why you use more complex macros, fact is indeed, that they sometimes are broken and then its totally messed up!

AoE placement, some Skills work, some not...
wait timer and cooldown from skills are messed up since spellspeed or skillspeed...

Since 1.0 i am using macros, but since 2.0 i just had problems with them!
Thats why i dont use them any more, its no fun and useless most of the time because totally messed up timings... you just cant rely on them any more!
Since 3.0 I just see players using them for Chat "pictures" or "sound"...