I run on less than max settings, because I like max fps at all times. I have noticed that a huge difference was made when I installed a solid state drive and put the game on that. But dual gtx580's in SLI with nvidia surround has allowed me to play at 5760x1920 at draw quality 8, everything else max, 16x AA, AO and DoF off. But my cards are screaming at that point. Still it looks damned good.