I use the mouse to click on buffs and click through my opener since I don't have to move for it. I have my most used skills from 1 to 5, AoEs on 7-8 and any positional/situational/skills with longer cool down or proc skills are actually big and floating around the mid screen so I can click on them mid-combat without wasting time or sacrificing movement. It's not all that pretty but it works for me.