So far, I have been fairly lucky with my neighbours.
Had a great neighbourhood back in the Mist with our tiny FC house, pretty much all houses around were active and we always met up at the market board
The friends I made there are now my best friends ingame as well as the FC I joined after I left the old one.
Last Christmas I bought my own house in Lavender Beds, and while it is a lot calmer and my neighbours aren't funny crazy people anymore that I can spend hour upon hours with,
I have met them and talked with all, and we sometimes visit each others houses. I see them at least once per week at the local MB, although I think I'm the only one who spends 99% of her non-instance playtime in her garden/house
It's fine though because my friends - despite having their own houses somewhere else - always hang around my house, even when I'm not there, so it still feels fairly lively^^
Then again, whenever I go around for inspiration and see that half of the new wards are still completely empty (except for maybe an aetheryte or a repair NPC), it really saddens me
Like...there are so many people who want a house - if you are not going to use it, leave it for those who really want one and would actually do stuff with it!