I guess it just depends on what you're used to..
the few times I have to use my keyboard I use WASD to move. I usually use my controller though and that's much more natural feeling to me. When I play melee, I lock on to targets and my character automatically moves around them so I'm not facing away from the enemy and losing out on autoattacks. (so then if I suddenly need to run away I can un-lock on and run instead of awkwardly back away...)