QWE movement (strafing and forward, back pedaling is bad so not bound)
R face target, T autorun
Hotbar1: 1234 ASDF ZXCV
Hotbar2: Alt + 1234 ASDF ZXCV
Hotbar3: Shift + 1234 ASDF ZXCV
Voice chat Push-to-talk: Ctrl (pressed with palm or bound on a mouse key)

Hotbar1: 1234 = combo 1, ASDF = combo 2, ZXCV = Aoes and other misc stuff or oGCDs. Horbar 2 and 3 have the buffs and the other stuff.

Works pretty well for minimized hand-stretching.