I'm just getting into the game and I've watched a few gameplay videos. One thing that jumps out at me is how many hotbars many of these people in the video have. I play with a Logitech G13 and a Razor Naga. After adding movement, inventory, character binds I have about 18 keys on the G13 and 12 on the Naga. Thats well short of the 3,4 even 5 hotbars I see people using in videos.

So my question is, how many buttons are really needed to be effective in endgame content..