I find myself slightly with Nek on this one. The pop up is bizarre, even if there is a way to remove it. Consider that the option unchecked by default is "open upon area change".

Why in the name of god would you need a pop-up link to a website spamming on your screen every time you change zones? If you're going to use a browser window for extra information on the game you are playing, can't you just find and bookmark links yourself like a sane person? And that's not even discussing that the "play-guide" isn't a very good website for information, in my opinion. I have 6 different FFXIV related bookmarks, and they all contain better information not contained within the official Eorzean database website.

This really should have been something they left in the launcher. The only reason to add something like this to the game was if it included enhanced support, such as opening a specific website page by selecting an "examine online" option when clicking items.