There's usually some profit to be made in crafting just about anything, simply due to market forces (if it's not profitable to craft and sell, people won't craft and sell it, so the price goes up and demand for mats goes down until it is profitable again), though some of the older items are getting an influx from quick ventures so it's always worth checking.

If you want to level just a few of the classes to endgame, alchemist and culinarian are typically safe bets since people will always need potions and food. I'd recommend taking everything to 60 as a futureproofing measure though. They've been doing a decent job at shaking up which classes have access to things and reducing the number of "useless" jobs (example, carpenter makes most of the crafting accessories now) and we won't know where the next random high demand recipe will come from.