Hm, it also depends what type of keyboard/mouse you will be using. As for example I couldn't play anymore without my Logitech G600 (it's a mouse ). On the side are keys for 1-0 (or whatever you bind) and I can all reach more or less comfortable with my thumb. With my left hand I use WASD QERT FG YXCV Alt Control Shift Tab Tilde Space (German key layout).