I would definitely play around a lot with keybinds. Similar to Dayala, I also gave up the 7-0 keys and use QERTFG to complete my 12 buttons for the hotbar. It just makes it that much easier to perform all actions while still keeping one finger on WASD ready to dodge stuff.

One thing I could not get used to, however, was clicking CTRL/Shift/Alt for other hotbars, so I actually purchased the Razer Mamba mouse. It very conveniently only has 2 large buttons on the side which I can click with my thumb. I bound those buttons to be Shift/Alt, so I don't have to stretch my hands pressing them on the keyboard with my pinky.

I would also recommend keeping the party list close to your character so while you're clicking and looking at the party list, your character is still in good vision of you. It will feel awkward at first but try sticking to it and you'll most likely never go back. I couldn't even do WASD movements when I started out but now I could never go back to pad. ;D