Better Wars can answer more specifically, but I assume you mean eye instead of path? You want the slashing debuff

I think it's slightly better to open with 2x eye combos before zerking the triple cleave, this makes sure the debuff stays up long enough

Personally I pop IR whenever it's off cd after the opener, it has a relative short cd time so I don't see any particular reason to delay it unless berserk is about to come back up (this happens around the 3rd berserk, iirc)