Your peripherals make a notable difference in how best to setup the UI to comfortable accommodate your style. I, personally, have a gaming keyboard and mouse, which I use to limit the amount of modifier keys I have to hold down. In fact, pre-Heavensward I only use Shift for one ability.

This would be my UI layout. I re-map targeting to my mouse, freeing up the Tab key. While it does show Shift/Alt, those keys are all re-mapped to specific buttons on my keyboard. If you have any questions though, I'm happy to help. ^^

Edit: Ignore the keybind tab in the corner. I've been experimenting and stuck it there so I could open that menu faster, xD