If you have issues using a mouse for long periods of time, it's possible to map nearly every function over to the keyboard with the exception of ground targeting. I swapped out WASD for the NUMPAD 4862 with strafing at 1 and 3. My thumb controls the camera, allowing me to run and adjust the camera angle on the fly. That leaves my left hand free to handle all macros. I use my thumb to smack the CTRL ALT and SHIFT keys to grant me access to three hotbars and a pet bar, and I have the keybinds mapped such that the keys I'll need to use while running can be accessed by the left hand, but keys I'll need to stand still to use are smacked by the right hand instead (e.g. bard songs, long cast spells on SMN, etc.)

It's a modified version of the FFXI layout, which was keyboard heavy and mouse light.