This issue seems to occur at almost random times. I've been watching my temperatures on my graphics card and it usually floats between 69-73 depending on instance. It's a GTX 980. I use two monitors, but only play on one of the screen. I usually play in windowed full screen 1920 x 1080, and have my settings on Maximum with my frames limited to 60.

Both monitors just simultaneously lose signal and refuse to turn back on without me holding the power button down on my computer and completely restarting it.

This issue does not occur on anything other games. That I play.