Right now, there is basically one gearing progression for players to follow. Only one set of 200 and one set of 210 gear exist in the game available to a given class, and maximizing your character generally means equipping as much of that as possible. While there are some exceptions to this (tanks in Alexander Savage generally want Slaying accessories right now, for instance), the case is generally that your BiS is what's at the top of the food chain--the augmented esoteric gear.
So naturally, right now, secondary stats don't really matter, and don't really do much for us. We don't have a choice in what to wear at the top, so debating whether Determination is better than Skill Speed is (relatively) pointless (though I only tank, I've heard this from DPS players in my FC).
But I look at the landscape in 2.5, and I can see that there were, in fact, multiple gear sets available at 120 and 130 iLvl, and multiple pieces, and iirc they had different stats on them. For example, the 120 Demon set had different stats than the 120 Magitek set.
So my question is, for those of you who were playing at that time, did stats matter more? Was best-in-slot a smorgasbord of pieces from several different sets? Or did it not really matter, since both sets were equally effective?