I did exact same as Pyretta did, I keybound F as "confirm" since keybinds were possible. (Comes from GuildWars2 that I happened to play back during 14 Beta, so I was used to it already.) And then there's the X-button on keyboard that removes all other players as targets and you can click the npc/object target (even through them if not otherwise visible) on the spot where cursor changes into a hand. Never have had any trouble targeting things with those two methods.

So I suggest those two methods to avoid clicking random targets with mouse and lose your nodes.