I've binded ctrl and shift to my mouse so I don't have to reach with my pinkie. I also go with the philosophy that you're more likely to hit a wrong hotkey the farther away it is so I rebind most of my hotkeys to stay on the left side; trying not to go past 5. If you looked at something like the razer orbweaver then that's kind of what I'm going for, except in the orbweaver you can move and push hotkeys at the same time.