The problem with "Target Nearest Enemy" (TNE) and similar options is specifically that it does not cycle between targets.

Acquiring a target, period, is not an issue for me, as tab already easily does that, it's acquiring the correct target, and quickly.

The main time I use tab cycling is when there are too many targets to quickly click the right one in a chaotic cluster of targets. This is especially true in Seal Rock, where minor latency between users results in targets bouncing around faster than players can move, making them even harder to click.

The mouse is imprecise with many closely packed and moving targets, and using TNE also does not let you navigate that cluster by itself. Using TNE and Tab Cycling in tandem still could target something ludicrously out of range, unfortunate in a rapid situation.

I assert that targeting functions do not make navigating easier whenever there are more targets, which is the main time clicking is also harder.

What would improve it would be more options to filter what it will tab to, like limiting the range tab can select targets, or the side of your character it will select from (instead of being based on the current position of the game camera), or even the function it uses to select the next target (like cycling between enemies near my current target instead of making a list of enemies to cycle through based on their at one moment proximity to me).

The current "Target Filters" under character customization seem to not be related to tab cycling but something with the game pad controller (I'd love for anyone that knows how they work to describe them for me and others here).