In A4S my warrior will tank some stuff in full slaying and he occasionally gets ganked. It depends on how much you trust your healers. If they keep you topped up most of the time you should be fine. The missiles hit for like 10-12k before mitigation, and there's a couple times when they'll hit at the same time that your DPS need to make their adds explode. That damage depends on how low the adds are. I've tried full slaying before (on dark knight) and I didn't really feel comfortable, but then again I also haven't cleared it.