Macros: generally bad, but a handful of exceptions.
Macros with 2-4 abilities on 1 button: Terribad. Stop. Dont. Please!

Unchained and zerk on 1 button? Gratz you can never use berzerk by itself when you need to because it will trigger unchained. Vengence and foresight? Now you can't use for sight without burning vengence for no reason.

Macros like this completely destroy your ability to use the right ability at the right time because it's a giant bundled mess in the name of 'convenience' and that's before we even touch the delay issues that have already been pointed out. Please don't encourage this kind of restrictive gameplay. All it does is limit you ability to play well.