How do you target successfully?

[Estellios]

Are you trying to hit the F keys after selecting cure on the action bar? Or are you using a macro that casts Cure on your current target? If it's the latter you might want to change the macro to <stparty> instead of <t> so you can hit the macro, then select a target.

[Aiko]

Make the following macro:

/ac "Cure III" <stpc>

Hit the macro to "load" the cure spell, then single click on someone's name in your party list, or press enter to cure yourself.

Only two "clicks" and no F keys.