Hi! My Cousin has MS and know (not first hand though) struggle and how difficult it can be. But Just so you know. I play on a PS4 and I use zero mouse clicks. I just cycle through the things I need via the buttons on my controller. Ive gotten very fast at it and I actually play faster and more controlled using a PS4 remote than a keyboard and mouse. Ive done Coil and all the hard content (minus savage Alex) using my ps4 remote and not once can anyone tell im on a ps4. Id say give it a shot