I play on controller and I love it, but there are some clear limits that you have to figure work arounds for.

- Hotbar space: Hotbar space is a premium on controller and almost requires the use of space saving macros to make an efficient bar setup. Tabbing through bars is clumsy at best in high pressure situations so I try to avoid it at all costs.

- Targetting Macros become a must with a controller format just to deal with crowds and the like in towns.

- Voice chat becomes more important too as typing while playing with a controller can get annoying.

I enjoy the freedom of movement that the controller provides though as it creates unique targeting opportunities... and I feel more natural with a controller in my hand. If your aware of its shortcomings and can get systems in place to counteract them then I don't see why controller use would be a hindrance at all.