Gathering Classes don't (and can't) use Specializations.

Comfort Zone, Hasty Touch, and Steady Hand II help a lot, and you'll get those by going CUL/ALCH. The new crafting skills and specializations make CRP's Byregot's Benediction less vital, but you will still be missing out a bit on it, and WVR's Careful Synthesis II is nice. You'll still be able to get a decent number of HQ results, but it's not as guaranteed as someone who brought everything to 50.