I usually used Unchained as part of my opener.

Infuriate -> Unchained -> Bloodbath -> Internal Release -> Berserk mixed in between my Maim/Storms combo.. it's usually enough to hold plenty of hate till I get off my enmity combo to follow. Then I use it any time it's up because it's almost always better to have the damage increase. Inner Beast hits and ignores Defiance... but Infuriate is every subsequent attack for it's duration ignores defiance penalty. It's much more damage than one inner beast.