I use the same setup as the OP. I have an injured wrist, and while I can type on a keyboard all day without thinking about it, using a mouse is really kind of painful, even with my fancy ergo mouse and a little bean bag wrist rest. I use the FFXI keybinds in which the right hand controls movement on the number pad (instead of WASD) and the camera, freeing up the left hand to control three rows of macros with the top row of numbers and CTRL and ALT.

The one place this falls apart is ground targeting, because that goes wherever the mouse cursor last was. I've gotten pretty good about sneaking in a mouse movement to the target and then hitting my Flame Arrow macro in the space of a global cooldown (usually in between my DoTs), but if I could have a macro line to move the cursor to my current target, it'd eliminate the need to touch the mouse at all during combat.