The targeting keys (F1-F5) introduced by a patch (cant remember which, maybe a December one) are a good thing.

Tho, they still arent 100% comfortable for one simple reason:
they dont work after an action is selected (both from action bar and <st> macros), making them almost useless, especially with a locked target.

Plus: with the new limit (still not introduced) of 8 players party, PLEASE make F1-F8 all target keys (where F1 targets the user, if not configurable).