It really depends on the debuff.

Most poisons aren't worth cleansing, and it's often more MP efficient to just slap a heal on the DPS.
Paralyze is worth removing basically all the time unless it's an exceptionally short duration paralyze.
Silence is a top priority to remove, especially if it's on another healer. If it's on a physical DPS though then whatever lol. Pacification is the same but lol on magical DPS.
Warrior's pacify is such a short duration that it's often not worth removing. If you can perfectly cast the pre-time you'll remove all 5 seconds, sure, but often you're going to be busy casting something else once Berserk ends, and by the time you can actually get around to cleansing it it'll be anywhere
from 4 to 2.5 seconds remaining in duration - and with Esuna having a 1 second cast time, not really worth it.

Most of the debuffs you'd really want to prioritize removing are esuna-immune though which sucks but oh well.