Some content it's not a good idea to remove the effect. As another said, Gilgamesh's Battle on the Big Bridge can bypass mechanics.

Other content, it's not possible to remove certain effects. Paralysis inflicted by Thunderstruck is an example, and a punishment for failing a mechanic.


I won't deny, there at times to remove the effects. Slow if possible is the biggest one for all classes, Paralyze should always prioritize casters, Disease on tanks, and certain DoT's like Melusine's Venomous tail have to be removed. Trust your healer to know whcih is best to remove, and which to ignore.

Lastly, some content it takes lower priority over actually healing because of a constant re-application of the debuff. Tam Tara Deepcroft's bosses that apply Poison is an example of this - try to esuna all the poisons, and you're more like to lose the tank or DPS to the damage you weren't healing than you saved yourself healing by remove those constantly-spammed effects.