I've been working on the "new" opener for 3.2, and this is what I've come up with. I've actually been using this for a while, but before the change it was roughly the same as most other openers. After 3.2, it will be significantly higher because it gets out 6 Ruin IIIs.

(Pre-cast) Shadowflare
(Pre-cast) Bio II
Miasma
Bio > Potion > Fester
Ruin III
Ruin II > Rouse > Spur
Ruin II > Enkindle > Raging Strikes
Ruin II > Painflare > Fester
Miasma II > Swiftcast > DWT
Ruin III > Tri-Disaster > Aetherflow
Ruin III x4 (Contagion)
Ruin II > Fester > Deathflare
Shadowflare

Here's the potency math behind this opener.
Here's a video demonstrating the opener.