I have a question:
when you re-apply dots, its optimal for dps/mana managements to apply as late as possible without letting them go off. So i cast bio 2 and miasma when dots are at 4ish seconds and bio at 2 seconds.

question is: how big issue is letting dots falling off? for example you cast bio 2 but before it is re-applied it falls of and 1 second later you re-apply it, are you losing a chunk of dps?