I feel like I better understood what you were trying to say after reading this tidbit. In a good party where the first add will die in 8 GCDs, the M / B setup is likely better.
However wouldn't this change if they are alive past 8 GCDs as well?
For example if you only dotted the 3 hourglasses not focused by the horde with all 3 DoTs (9 GCDs), you would be doing 330 potency universally in one tick by the time the final bio lands on the third add.
The first Bio would be at about 2 seconds or so. From here on you could technically ignore Bio II falling off on the first add (about 10 seconds or so left here, because your assuming it will die in those 10 seconds) and just refresh Miasma and Bio on the hourglasses, and overall that would give you more potency universally no? For about an additional 10 seconds or (3 to 4 server ticks depending on where you land on the server timer) you are doing 330 potency. Unless my math is completely wrong here.
This is more or less the way I make those calls as well. Although assuming we keep the same DPS as well, in repeat attempts yes, it would be Miasma over Bio II for that little bit of potency.