I don't use macros.

My key setup is fairly simple

Numbers (1,2,3..etc.)
Ctrl+numbers (ctrl+1, ctrl+2, ctrl+3..etc.)
Shift+numbers (shift+1, shift+2, shift+3..etc.)
R & F
2 Mouse Side Buttons (Simple forward/back buttons that can be found on many mice)
I use Q&E to strafe

Here's my UI if you're curious