http://i.imgur.com/F39CJUB.jpg

http://i.imgur.com/tO7af6c.jpg

This is how I have mine set up. Important skills are linked to Q, E, R, and T since I can tap them with my index and ring fingers while I use my middle finger to hit W if I need to move forward and mudras are placed where I can get to them easily (using a logitech g600 mouse so I just have to move my thumb down to the last 3 buttons that way I don't accidentally hit any of the other buttons).