Tupsimati simply doesn't interest them. As Myahele mentioned, It's a tool for channeling incredible amounts of aether, extremely helpful in summoning primals. Tupsimati isn't the only "key" in our realm either. So, why would the seal be just on that one?
Here's my take on things:
The crystals are Hydaelyn's power, and Hydaelyn is the crystals all made one.
The crystals have, in someway or another, always existed, and so too the barrier which repels the darkness. This "seal" prevents agents of the darkness from taking form in the realm of light, making difficult their ability to detect aetherial signatures, the likes of which are present in certain objects (Tupsimati).
Through the story we literally collect pieces of Hydaelyn, scattered by time throughout the realm, and, once together, allow her power to emerge.
We hear from her last at the end of 2.0 before being shown a darkened Mothercrystal - her power in its entirety nigh expended from the recent battle. Later, in 2.5, Midgardsormr communes with and finds her power waning. There isn't much left, he suggests to the Warrior of Light. So, using the remainder, he creates for himself a new form from Hydaelyn, as commanded by Hydaelyn, to watch over and aid her Champion against the encroaching darkness. The crystals, completely drained of their power now, shatter, removing the "Blessing of Light" from the player and breaking the seal that kept the dark ones at bay.
Nabriales, now able to freely enter our realm, sought Tupsimati out of desperation for greater power, as he seeks to take Elidibus' seat next to Zodiark.




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