You can move while pressing down on mouse L+R as well, which I often use. I could also select targets using the mouse while moving with my keyboard. I think essentially controller mode is very precisely optimized for the game, while keyboard-mouse mode is the usual versatility mode that can end up better or worse than the controller entirely depending on individual preferences.
Personally I find the camera control on the controller quite imprecise.
The keyboard-mouse mode need a lot of keybinds customization. For example, my left hand covers 48 key-binds without having to move its position even 1 inch.
In the end it's all just personal preferences.