When it comes to esuna it's a good idea to learn about debuffs and what they do. some can wait or be ignored so you can learn them and make a priority list there are some debuffs that need to be removed instantly or a person can die from it. Things like Disease which lower the amount of healing received you want to get rid of fast but a weak poison won't cause too many problems. Paralyze won't cause too many problems for melee like the MNK but BLM's with long cast times will be crippled by it so priority after Tanks is the BLM's These are just some examples but knowing what all debuffs look like and what they do can make your cleansing more efficient.