Honestly, the only rule that's of any fun with the current NPC setup (with them having typically only good cards with 1 or 2 extra good cards to play), is Plus and MAYBE Ascension or Sudden Death. Without those rules, you pretty much stand no chance unless the NPC does something stupid in your quest to obtain 30 cards (and then 60+). Thankfully, they do stupid things from time to time. Random generally involves loss after loss, until the NPC does something stupid (again). Ditto for Chaos or any of those other irrelevant to 4-5 star deck rules.