How do you best optimize playing with the PS4 controller?

[ChameleonMS]

A lot of times in a dungeon using the D-Pad seems to select everything but the enemy, going through NPCs or Treasure Chests first.

I have edited my selection filters when my weapon is drawn. This way I cannot select anything but enemies when cycling (left and right) with the D-Pad. My target selection is everything while weapon is sheathed.
This also helps a bunch in FATES, as NPCs are no longer targeted while drawn.
If I need to interact with an object, face the object, a quick Circle (remove current target selection) then L3 to sheath my weapon and double press X for the object selection and activation.

For those few quests, where you have "heal" some NPC I adjusted my settings for that quest instance and then switch it back. I only remember doing this a few times.