Wow, I never even thought of casting esuna/leeches - I guess either it doesn't hit me that often, when it does I don't really care. (Which reminds me - FFXIV doesn't have a generic Remedy potion, does it?)

I really noticed heavy when I was lv10 trying to explore the entire world (on foot, mind you!) That was fun. ;-)

My favorite irritating debuff (which I usually avoid in case it's not silenced and now he dies in a few seconds anyway) is Kurrea's sleep...