The thing that annoys me is that if you precast Esuna/Leeches even by one microsecond too much, it won't have any effect at all. And if you wait till the debuff pops out, you'll only shave off around one GCD off of it =/ (Less if you're forced to wait for your GCD cos it had no effect >.< )
Sure, that GCD can be important sometimes, but not always, especially if there's MP left for Flash. I'll do my best to get rid of Pacify even without macros, if I notice it in time, but if the first Esuna/Leeches fails, I'm most likely not going to make another attempt ^^;

(Though on that note, I've had both lovely and not-so-lovely reactions... This one tank in Brayflox NM paused for a few seconds after the trash group was downed, and then we got the message "OMG did you just Esuna my Pacification? You did! I love you!" ♥
And this other tank with a macro who downed the group just as berserk wore off, and then berated me for not Leeching him during the five or six seconds it took us to run to the next group... -_- Thus further delaying the next pull by the time it took him to type that. That was just... What?)