No, and for good reason.

However there is a suggestion in the UI forums to allow a macro to replace a macro. Which, if you so chose to create, could be used to place a skill chain on a single button amongst other things. Upvote please!

http://forum.square-enix.com/ffxiv/t...os-with-hotbar

This as already somewhat doable, but limited, with hotbar swaps, and I'd be happy to educate you how, if you express interest.