For the acn quest, since I see it mentioned a lot here, it is all about getting all the mobs on your radioactive rat, then moving it away from everything else. You will need to assist healing it occasionally but if you keep the mobs off the npcs they will heal the bajesus out of it while mowing the mob down, freeing you up to focus your attention on the heal/nuker threats. Cycling targets and using the attack command is enough to pull threat to your carby as npcs generate hate at a much reduced level than players.