Quote Originally Posted by SeraviEdalborez View Post
It has a use on most classes. The only ones it doesn't have a supremely obvious use for are BRD and tanks.

Casters/DPSing Healers: Obvious.
Melee DPS: Use during LB cast time.

It's a useful key to have bound in virtually all situations. Why waste the macro space when you can have a universal button for it? Do you bind Sprint separately on each class? Mount? LB? Jump?
I don't bind LB, just click it, but personally I only use a face target button/macro on casting classes (WHM/BLM/SMN/SCH) and just use smart movement and the "Automatically face target when performing actions" option checked in my character settings. I do not like lock-on, as I find it slightly annoying when I have to move, because I basically only ever move either by strafing or running forward, so I don't miss my AA's. But thats just me and how it works for me. Your milage may vary.